Research Objectives:

The Zhou lab focuses on the elucidation of the structure, dynamics, and function of protein-protein and protein-ligand interactions and their roles in various cellular processes. Our current efforts are directed toward enzymes and protein complexes involved in bacterial membrane biosynthesis, co-transcriptional regulation, and translesion DNA synthesis. In order to achieve these goals, the Zhou lab integrates a variety of biochemical and biophysical tools, including NMR, X-ray crystallography, enzymology, and others. The lab has also played a major role in development and application of innovative NMR technologies, including automated resonance assignment and structural analysis tools and high-resolution, high-dimensional spectral reconstruction techniques.


NMR Methodology & Software

 Computer-assisted Sequential Assignment Based on Exhaustive Search - PACES

 Fast NMR with Sparsely Sampled Time Domain Data and Spectral Reconstruction


Bacterial Membrane Biosynthesis

 


Translesion Synthesis